Beilstein J. Org. Chem.2015,11, 1713–1720, doi:10.3762/bjoc.11.186
hydroxylations.
Keywords: activesitemutagenesis; biotransformation; C–H activation; cytochrome P450cam monooxygenase; hydroxylation; Introduction
Selective C–H activation and oxyfunctionalisation of hydrocarbons offers a route to chiral alcohols and other industrially important synthetic building blocks from
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Graphical Abstract
Figure 1:
Library generation of P450cam[Tyr96Phe]-RhFRed. Active site of the P450cam-RhFRed variant Tyr96Phe ...